Functional Tissue EngineeringFarshid Guilak, David L. Butler, Steven A. Goldstein, David Mooney Springer Science & Business Media, 20 apr 2006 - 426 pagina's Tissue engineering is an exciting new field at the interface of engineering and - ology that uses implanted cells, scaffolds, DNA, proteins, protein fragments, and inductive molecules to repair or replace injured or diseased tissues and organs. Tremendous progress in biological and biomaterial aspects of this field have been accomplished to date, and several engineered tissues are now being used clinically. However, tissue engineers face major challenges in repairing or repl- ing tissues that serve a predominantly biomechanical function. To meet this challenge, the United States National Committee on Biomech- ics in 1998 adopted a new paradigm termed functional tissue engineering (FTE) to emphasize the importance of biomechanical considerations in the design and - velopment of cell and matrix-based implants for soft and hard tissue repair. Functional tissue engineering represents a relevant and exciting new discipline in the field of tissue engineering. Since many tissues, such as those of the muscu- skeletal, cardiovascular, and dental systems, are accustomed to being mecha- cally challenged, tissue-engineered constructs used to replace these tissues after injury or disease must certainly do the same. Of course, tissue engineers must also attempt to return normal biological activity in order for the construct to truly - tegrate with the surrounding tissues. Thus, the term functional can have many meanings, such as restoration of metabolic function. The primary focus of this text is on the role of biomechanical function in tissue engineering. |
Inhoudsopgave
Present Status and the Future of Functional | 17 |
Guidelines | 35 |
Functional Properties of Native Articular Cartilage | 46 |
Measurements | 69 |
Functional Requirements for the Engineering of a Blood Vessel Substitute | 87 |
In Vivo Force and Strain of Tendon Ligament and Capsule | 96 |
Requirements for Biological Replacement of the Articular | 106 |
Cartilage | 117 |
The Role of Mechanical Forces in Tissue Engineering | 227 |
University of California San Diego Jay D Humphrey | 233 |
Biomechanics of Native and Engineered Heart Valves Tissues | 243 |
Assessment of Function in TissueEngineered Vascular Grafts | 258 |
Assessment of the Performance of Engineered Tissues in Humans | 268 |
Functional Tissue Engineering and the Role of Biomechanical | 277 |
Regulation of Cellular Response to Mechanical Signals | 291 |
Artificial Soft Tissue Fabrication from CellContracted Biopolymers | 305 |
Design Parameters for Functional Tissue Engineering | 129 |
Massachusetts Institute of Technology La Jolla CA 920930411 | 142 |
Design Parameters for Engineering Bone Regeneration | 146 |
The Potential Uses of Gene | 162 |
Functional Tissues Organs and Interfaces | 178 |
Bioengineering the Growth of Articular Cartilage | 194 |
Assessment of Function in Engineered Tissues 211 | 213 |
Overige edities - Alles bekijken
Functional Tissue Engineering Farshid Guilak,David L. Butler,Steven A. Goldstein,David Mooney Gedeeltelijke weergave - 2003 |
Functional Tissue Engineering Farshid Guilak,David L. Butler,Steven A. Goldstein,David Mooney Geen voorbeeld beschikbaar - 2004 |
Functional Tissue Engineering Farshid Guilak,David L. Butler,Steven A. Goldstein Geen voorbeeld beschikbaar - 2014 |
Veelvoorkomende woorden en zinsdelen
activity adhesion alignment aortic arteries articular cartilage Ateshian behavior biochemical Biol biological Biomaterials Biomech biomechanical Biomed bioreactors blood vessel Bone Joint Surg bovine cardiac carti cellular chanical chondrocytes Clin clinical collagen compression contractility cruciate ligament culture cyclic defects deformation differentiation dynamic effects elastic engi engineered cartilage engineered tissue environment ex vivo explants extracellular matrix fibroblasts fluid force functional tissue engineering gene therapy Grodzinsky growth factor Guilak healing human implantation increased injury integrins knee layers loading Maroudas material measured mechanical properties medial medial collateral ligament ment mesenchymal mesenchymal stem cells modulus molecules muscle fibers neered normal Orthop osteoarthritis parameters patellar Physiol physiological potential pressure proteins proteoglycan rabbit regeneration remodeling repair response role scaffolds shear stress signals skeletal muscle stem cells stimulation strain structure studies surface synthesis tendon tensile testing tion tissue engineering transducer ture Vandenburgh viscoelastic vitro