Functional Tissue Engineering

Voorkant
Farshid Guilak, David L. Butler, Steven A. Goldstein, David Mooney
Springer Science & Business Media, 20 apr. 2006 - 426 pagina's
Tissue engineering is an exciting new field at the interface of engineering and - ology that uses implanted cells, scaffolds, DNA, proteins, protein fragments, and inductive molecules to repair or replace injured or diseased tissues and organs. Tremendous progress in biological and biomaterial aspects of this field have been accomplished to date, and several engineered tissues are now being used clinically. However, tissue engineers face major challenges in repairing or repl- ing tissues that serve a predominantly biomechanical function. To meet this challenge, the United States National Committee on Biomech- ics in 1998 adopted a new paradigm termed functional tissue engineering (FTE) to emphasize the importance of biomechanical considerations in the design and - velopment of cell and matrix-based implants for soft and hard tissue repair. Functional tissue engineering represents a relevant and exciting new discipline in the field of tissue engineering. Since many tissues, such as those of the muscu- skeletal, cardiovascular, and dental systems, are accustomed to being mecha- cally challenged, tissue-engineered constructs used to replace these tissues after injury or disease must certainly do the same. Of course, tissue engineers must also attempt to return normal biological activity in order for the construct to truly - tegrate with the surrounding tissues. Thus, the term functional can have many meanings, such as restoration of metabolic function. The primary focus of this text is on the role of biomechanical function in tissue engineering.
 

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Inhoudsopgave

Present Status and the Future of Functional
17
Guidelines
35
Functional Properties of Native Articular Cartilage
46
Measurements
69
Functional Requirements for the Engineering of a Blood Vessel Substitute
87
In Vivo Force and Strain of Tendon Ligament and Capsule
96
Requirements for Biological Replacement of the Articular
106
Cartilage
117
The Role of Mechanical Forces in Tissue Engineering
227
University of California San Diego Jay D Humphrey
233
Biomechanics of Native and Engineered Heart Valves Tissues
243
Assessment of Function in TissueEngineered Vascular Grafts
258
Assessment of the Performance of Engineered Tissues in Humans
268
Functional Tissue Engineering and the Role of Biomechanical
277
Regulation of Cellular Response to Mechanical Signals
291
Artificial Soft Tissue Fabrication from CellContracted Biopolymers
305

Design Parameters for Functional Tissue Engineering
129
Massachusetts Institute of Technology La Jolla CA 920930411
142
Design Parameters for Engineering Bone Regeneration
146
The Potential Uses of Gene
162
Functional Tissues Organs and Interfaces
178
Bioengineering the Growth of Articular Cartilage
194
Assessment of Function in Engineered Tissues 211
213
Signaling to Mechanical Load in Connective
318
From Macroscopic to Microscopic
347
In Vitro
360
Tissue Engineering Skeletal Muscle
377
Preclinical Evaluation
395
Index
405
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