Images de page
PDF
ePub

Research on the biological effects of ionizing radiation is being supported or conducted by the following departments and agencies:

DEPARTMENT OF AGRICULTURE

DEPARTMENT OF COMMERCE

National Bureau of Standards

DEPARTMENT OF DEFENSE

DEPARTMENT OF ENERGY

DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE

Office of Health Research, Statistics, and Technology

National Center for Health Statistics

Center for Disease Control

National Institute for Occupational Safety and Health
Bureau of Epidemiology

Food and Drug Administration

Bureau of Radiologic Health

National Institutes of Health
National Cancer Institute
National Institute of Environmental Health Sciences

DEPARTMENT OF TRANSPORTATION

Federal Aviation Administration

ENVIRONMENTAL PROTECTION AGENCY

NATIONAL AERONAUTICS AND SPACE ADMINISTRATION

NATIONAL SCIENCE FOUNDATION

NUCLEAR REGULATORY COMMISSION

VETERANS ADMINISTRATION

, EDUCATION

NATIONAL INSTITUTE OF HEALTH
Subcommittee to develop Federal Research

DATE: OCT 4 gre
Strategy into Biological Effects of
Ionizing Radiation

[blocks in formation]

The exceptionally tight schedule we have accepted to develop a Federal strategy on research into the biological effects of ionizing radiation requires that we proceed expeditiously. Accordingly, I will convene the first meeting of the Subcommittee as follows.

[blocks in formation]

Our goal for Tuesday is to structure a meeting of non-Federal
consultants to be held during the week of November 5. Based on
availability of space, we have tentatively identified the 7th of
November for this event.

To meet this responsibility, the Subcommittee must accomplish a
mmber of tasks.

1. Review the draft strategy distributed at the cammittee meeting
on September 25, making additions, deletions, or changes as required.
The product produced at this meeting on October 9 should be sufficiently
complete to provide the frame of reference for discussions at the larger
meeting on November 7.

2. Identify non-Federal consultants (3-6 in each primary research area identified in the strategy) to meet on November 7.

3. Prepare a list of prospective authors for position papers covering
both disciplinary areas and cross cutting issues. These scientists
must be senior investigators with the skill, knowledge, and perspective
to prepare authoritative statements in areas to be identified by the
Subcommittee.

Page 2 - Subcommittee to develop Federal Research Strategy into

Biological Effects of ionizing Radiation

While for tasks 2 and 3 you should be prepared to name scientists that will address research issues of importance to your agency, you can feel free to consider the needs of other Federal programs.

NIH will assume responsibility for logistic support of the November conference and, I would anticipate that subcommittee members will all play vital parts in that meeting. The actual roles can be defined with greater precision at our meeting on October 9, or at such subsequent meetings as the Subcommittee deems necessary.

For your convenience, I am enclosing copies of the relevant material distributed at the meeting of the parent committee on September 25.

I hope you understand the issues which prompt me to move ahead with such urgency. We all have a vital stake in the success of the final product.

[ocr errors][merged small]

Scientific Issues and Questions

1. Risk Factors - Populations (High risk) 2. Interpretation of In Vitro Cell Testing - Extrapolation from in vitro

to in vivo 3. Repair - Dose rate issues, temporal effects (latent periods) 4. Animals to Humans - Proper choice of models 5. Epidemiology - What can and cannot be done 6. Synergisms and Antagonisms 7. Nature of Dose Response Curves - Projection models 8. Radiation Quality - LET problem 9. Precursor Injury and Repair 10. Non-cancer and Non-genetic Effects 11. Dose Rate Issues - Cumulative dose, fractionation 12. Treatment - Prophylaxis, therapy

Draft Outline

Federal Strategy for Research Into the Biological

Effects of Ionizing Radiation

1. Radiation Physics

A. Macrodosimetry - time and space relations
B. Microdosimetry - time and space relations
C. Background radiation

II. Radiation chemistry and radiation modifiers in biological systems
III. Radiation cell biology

A. Damage and repair processes (normal and tumor cells)
B. End effects

1. cell killing
2. mutagenesis
3. transformation

4. developmental processes
C. Interactions with viruses and chemicals

D. Genetic determinants
IV. Genetic effects (hereditary)

A. Chromosome breakage
B. Gene mutation - extrapolation from experimental systems to

humans (EFESTH)
C. Cumulative effects
Long range effects

1. background genetic disease
2. sensitive populations
3. rate of discount for future disease

[blocks in formation]

A. Cancer

1. tissue and cell sensitivity, inducibility, incidence

time course of events
projection models of future disease risk

EFESTH
5. cofactors, host factors

dose rate, radiation quality
dose response models

« PrécédentContinuer »