Biomedical Chemistry: Applying Chemical Principles to the Understanding and Treatment of DiseasePaul F. Torrence John Wiley & Sons, 24 jan 2000 - 432 pagina's How basic chemical ideas help advance the understanding and treatment of disease Biomedical Chemistry presents clear, concise coverage of the application of chemistry to drug discovery and determination of disease etiology, highlighting its role in the explosive growth of biotechnology and molecular biology. Through expert contributions from leading researchers in diverse fields, the book provides readers with an understanding of how fundamental chemical concepts are used in the development of novel approaches to the major problems in medicine today. The authors explain both the science and reasoning underlying each experimental approach, exploring cutting-edge developments in AIDS, cancer, alcoholism, Parkinson's disease, trypanosomiasis, emphysema, and malaria. Contemporary research problems discussed include: * Mechanism-based drug discovery * Design of new antitumor and antiviral agents * Targeting tumors using magnetic drug delivery * Antisense and antigene agents Easily accessible to anyone with a solid undergraduate background in chemistry, Biomedical Chemistry is an excellent resource for researchers in health-related fields as well as anyone seeking an overview of frontier topics in medicinal chemistry, organic chemistry, and biochemistry. |
Inhoudsopgave
DRUG DISCOVERY AND DEVELOPMENT LEADS FROM | 1 |
The Chemistry | 7 |
MechanismBased SAdenosylLHomocysteine Hydrolase Inhibitors | 41 |
Aldehyde Dehydrogenase Inhibitors as Alcohol | 73 |
Adenosine DeaminaseActivated Prodrugs for the Treatment | 99 |
Basis for the Rational | 115 |
EXPLORATION OF FUNDAMENTAL CHEMICAL | 143 |
Phosphoryltyrosyl Mimetics as Signaling Modulators | 189 |
Fluorine Substitution as a Modulator of Biological Processes | 247 |
UNDERSTANDING THE CHEMICAL BASIS OF DRUG | 267 |
CarbonCentered Radicals and Rational Design of | 289 |
The Chemistry of Parkinsons Disease | 311 |
NOVEL CHEMISTRIES IN THE VANGUARD | 347 |
Towards Gene Therapeutic Drugs | 371 |
The Evolution of GeneSpecific Chemotherapy | 385 |
| 405 | |
Targeting Tumors Using Magnetic Drug Delivery | 211 |
Superacid Generation of New Antitumor Agents | 227 |
Veelvoorkomende woorden en zinsdelen
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