Biomedical Chemistry: Applying Chemical Principles to the Understanding and Treatment of Disease

Voorkant
Paul F. Torrence
John Wiley & Sons, 24 jan. 2000 - 415 pagina's
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How basic chemical ideas help advance the understanding and treatment of disease Biomedical Chemistry presents clear, concise coverage of the application of chemistry to drug discovery and determination of disease etiology, highlighting its role in the explosive growth of biotechnology and molecular biology. Through expert contributions from leading researchers in diverse fields, the book provides readers with an understanding of how fundamental chemical concepts are used in the development of novel approaches to the major problems in medicine today. The authors explain both the science and reasoning underlying each experimental approach, exploring cutting-edge developments in AIDS, cancer, alcoholism, Parkinson's disease, trypanosomiasis, emphysema, and malaria. Contemporary research problems discussed include:
* Mechanism-based drug discovery
* Design of new antitumor and antiviral agents
* Targeting tumors using magnetic drug delivery
* Antisense and antigene agents
Easily accessible to anyone with a solid undergraduate background in chemistry, Biomedical Chemistry is an excellent resource for researchers in health-related fields as well as anyone seeking an overview of frontier topics in medicinal chemistry, organic chemistry, and biochemistry.
 

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Inhoudsopgave

DRUG DISCOVERY AND DEVELOPMENT LEADS FROM
1
MechanismBased SAdenosylLHomocysteine Hydrolase Inhibitors
41
Aldehyde Dehydrogenase Inhibitors as Alcohol
73
Adenosine DeaminaseActivated Prodrugs for the Treatment
99
Basis for the Rational
115
EXPLORATION OF FUNDAMENTAL CHEMICAL
143
Phosphoryltyrosyl Mimetics as Signaling Modulators
189
Targeting Tumors Using Magnetic Drug Delivery
211
Fluorine Substitution as a Modulator of Biological Processes
247
UNDERSTANDING THE CHEMICAL BASIS OF DRUG
267
CarbonCentered Radicals and Rational Design of
289
The Chemistry of Parkinsons Disease
311
NOVEL CHEMISTRIES IN THE WANGUARD
347
Towards Gene Therapeutic Drugs
371
The Evolution of GeneSpecific Chemotherapy
385
Index
405

Superacid Generation of New Antitumor Agents
227

Veelvoorkomende woorden en zinsdelen

Over de auteur (2000)

PAUL F. TORRENCE, PhD, is Professor and Chair of Chemistry at Northern Arizona University in Flagstaff, and formerly Chief of the Biomedical Chemistry Section, Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, and Director of the Foundation for Advanced Education in the Sciences Graduate School at the National Institutes of Health. Dr. Torrence is widely recognized for his contributions to medicinal chemistry and has published more than 190 scientific papers and patents.

Bibliografische gegevens