Basic Clinical Radiobiology

Voorkant
Michael C. Joiner, Albert J. van der Kogel
CRC Press, 28 aug 2018 - 360 pagina's

Basic Clinical Radiobiology is a concise but comprehensive textbook setting out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics, and radiation technology.

Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, this fifth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.

This new edition is highly illustrated with attractive 2-colour presentation and now includes new chapters on stem cells, tissue response and the convergence of radiotherapy, radiobiology, and physics. It will be invaluable for FRCR (clinical oncology) and equivalent candidates, SpRs (and equivalent) in radiation oncology, practicing radiation oncologists and radiotherapists, as well as radiobiologists and radiotherapy physicists.

 

Geselecteerde pagina's

Inhoudsopgave

Preface
Irradiationinduced damage and the DNA damage response
How when and why cells
Quantifying cell kill and cell survival
Radiation doseresponse relationships
Linear energy transfer and relative biological effectiveness
Physics of radiation therapy for the radiobiologist
Tumour growth and response to radiation
Normal tissue tolerance and the effect of dose inhomogeneities
The oxygen effect and therapeutic approaches to tumour hypoxia
The tumour microenvironment and cellular hypoxia responses
Combined radiotherapy and chemotherapy
Molecular targeted agents for enhancing tumour response
Biological individualisation of radiotherapy
Molecular image guided radiotherapy
Retreatment tolerance of normal tissues

The linearquadratic approach
The linearquadratic approach in clinical practice
Modified fractionation
Time factors in normal tissue responses to irradiation
The doserate effect
Pathogenesis of normal tissue side effects
Stem cells in radiotherapy
Basic principles and pitfalls
The clinical aspects
Tissue response models
Second cancers after radiotherapy
Glossary
Index

Overige edities - Alles bekijken

Basic Clinical Radiobiology
Michael C. Joiner,Albert J. van der Kogel
Gedeeltelijke weergave - 2018
Basic Clinical Radiobiology, Fifth Edition
Michael C. Joiner,Albert van der Kogel
Geen voorbeeld beschikbaar - 2016

Veelvoorkomende woorden en zinsdelen

accelerated activation applied assay associated beam biological breast calculated cancer carcinoma changes Chapter chemotherapy clinical clonogenic combined compared curve damage depends described determined distribution dose dose per fraction drugs early effects endpoints energy estimated et al example experimental expression factor Figure fraction function given growth head and neck higher human hypoxia hypoxic imaging important improved increase indicates initial interaction IntJ Radiat Oncol irradiation late lead less limited loss lung measured mechanisms methods normal tissue observed occur Oncol Biol Phys Oncology organ overall oxygen parameters patients phase planning potential predictive probability proliferation proteins Radiat Oncol Biol radiation dose radiation-induced radiosensitivity Radiother radiotherapy range reduced relationship relative repair repopulation response risk sensitivity shown shows significant specific stem cells studies therapy tolerance toxicity treated treatment trial tumour cells tumour control types volume

Over de auteur (2018)

Michael Joiner: Professor of Radiobiology, Wayne State University, USA

Albert van der Kogel: Emeritus Professor of Radiobiology, Radboud University Nijmegen Medical Centre, The Netherlands; also Department of Human Oncology, University of Wisconsin, USA

Bibliografische gegevens

TitelBasic Clinical Radiobiology
RedacteursMichael C. Joiner, Albert J. van der Kogel
Editie5, geïllustreerd
UitgeverCRC Press, 2018
ISBN0429955391, 9780429955396
Lengte360 pagina's
  
Citatie exporterenBiBTeX EndNote RefMan