Annual Reports in Combinatorial Chemistry and Molecular DiversityW.H. Moos, M.R. Pavia, B.K. Kay, Andrew D. Ellington Springer Science & Business Media, 30 apr 1997 - 354 pagina's Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed, more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. This first volume covers: (i) combinatorial chemistry, (ii) combinatorial biology and evolution, and (iii) informatics and related topics. Within each section chapters are prepared by experts in the field, including, for example, in Section I: Coverage of mixture pools vs. parallel individual compound synthesis, solution vs. solid-phase synthesis, analytical tools, and automation. Section II highlights selection strategies and library-based evolution, phage display, peptide and nucleic acid libraries. Section III covers databases and library design, high through-put screening, coding strategies vs. deconvolutions, intellectual property issues, deals and collaborations, and successes to date. |
Inhoudsopgave
Combinatorial Chemistry | 1 |
A perspective | 3 |
Techniques for mixture synthesis | 6 |
Techniques for singlecompound synthesis | 19 |
Recent advances in solidphase synthesis | 30 |
Selection of supports for solidphase organic synthesis | 41 |
Solutionphase combinatorial chemistry | 50 |
Liquidphase synthesis | 54 |
Molecular evolutionary biology | 153 |
Lessons from in vitro selection experiments with nucleic acids | 169 |
Synthetic peptide libraries | 192 |
Phage display | 210 |
Informatics and Related Topics | 261 |
A perspective | 263 |
Modern chemical and biological databases | 265 |
Practical high throughput screening | 271 |
Analytical methods for the quality control of combinatorial libraries | 59 |
Automated synthesis | 69 |
Applications of combinatorial technology to drug discovery | 78 |
Combinatorial Biology and Evolution | 91 |
A perspective | 93 |
Models and search strategies for applied molecular evolution | 95 |
Deconvolution methods in solidphase synthesis | 285 |
Patent strategies in molecular diversity | 296 |
Review of deal structures | 312 |
The promise fulfilled? | 319 |
A compendium of solidphase chemistry publications | 324 |
Overige edities - Alles bekijken
Annual Reports in Combinatorial Chemistry and Molecular Diversity W.H. Moos,M.R. Pavia,B.K. Kay,Andrew D. Ellington Gedeeltelijke weergave - 1997 |
Annual Reports in Combinatorial Chemistry and Molecular Diversity M. R. Pavia,W. H. Moos Geen voorbeeld beschikbaar - 2014 |
Annual Reports in Combinatorial Chemistry and Molecular Diversity W.H. Moos,M.R. Pavia,B.K. Kay,Andrew D. Ellington Geen voorbeeld beschikbaar - 2014 |
Veelvoorkomende woorden en zinsdelen
Acad active affinity distribution amino acids antibody approach aptamers assay automated beads best ligand binding clones Biol biological Bioorg cells chain Chem chemical claims combinatorial chemistry combinatorial libraries complex compounds deconvolution developed drug discovery Ellman encoding enrichment epitope equilibrium evolutionary example fitness landscapes function gene high affinity Houghten inhibitor initial interaction laboratory Lebl ligands linker loxP method mixture mole fraction Molecular Diversity molecular evolution molecules motifs mutation rate Natl nucleic acid optimal Pept peptide libraries phage display phagemid pharmaceutical pIII plasmid pool population Proc properties protein R₁ random sequence reaction reagents receptor recombination resin Robotics round sample Santa Fe Institute screening secondary structures selection sequence space solid support solid-phase synthesis solution-phase specific strategy stringency sublibraries tags target concentration techniques Tetrahedron Lett tion U.S. Patent variants vector washing Zuckermann