Endoplasmic Reticulum Stress in Health and DiseasePatrizia Agostinis, Samali Afshin Springer Science & Business Media, 13 aug 2012 - 452 pagina's The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases. |
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Endoplasmic Reticulum Stress in Health and Disease Patrizia Agostinis,Samali Afshin Geen voorbeeld beschikbaar - 2012 |
Endoplasmic Reticulum Stress in Health and Disease Patrizia Agostinis,Samali Afshin Geen voorbeeld beschikbaar - 2014 |
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Acad Sci U S A acid adipocytes angiogenesis apoptosis apoptotic associated ATF4 ATF6 autophagy Biochem Biol Chem Ca2+ signaling calcium calnexin calreticulin cancer cells cell death cellular chaperones CHOP complex cytosolic degradation disease domain endoplasmic reticulum stress enhanced enzymes ER stress ER-mitochondria ER-stress ERAD eukaryotic expression function gene Genet glucose glycosylation Golgi hepatic homeostasis immunogenic increased inflammation inhibition inhibitor inositol insulin insulin resistance interaction intestinal intracellular IP3R IRE1 Kaufman RJ leading lipid lipogenesis liver mammalian mechanisms mediated membrane metabolic mice microRNA miRNA misfolded proteins mitochondrial modulate molecular mRNA mTOR mutations Natl Acad Sci neurons obesity organelles oxidative pancreatic PERK phosphorylation pro-apoptotic Proc Natl Acad proteasome protein folding protein kinase receptor regulation role secretory SERCA signaling pathways stress response stress-induced target thapsigargin tion tissue transcription factor translation triggers tumor ubiquitin unfolded protein response up-regulation UPR activation UPR signaling XBP1 Zhang