Hepatic De Novo Lipogenesis and Regulation of Metabolism

Voorkant
James M. Ntambi
Springer, 17 dec. 2015 - 305 pagina's

The liver is the largest solid vital organ in mammals that supports other organ in the body in some facet. This book synthesizes all the primary and relevant metabolic information that one needs to review to understand the complex and diverse role of the liver in metabolism.

With the current epidemic of metabolic diseases, it is of immediate importance to understand the contribution of the liver in health and its role in the development of impaired metabolic regulation. This book covers the many studies that have unmasked important roles that proteins expressed in the liver play in the development of or protection from metabolic diseases.

One of the major metabolic functions of the liver is to carry out de novo lipogenesis, which is the metabolic pathway that allows the conversion of excess carbohydrates into fatty acids. The process of de novo lipogenesis is covered in depth within this volume. The book is an important contribution to the vast literature and ongoing research on liver function.

 

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Inhoudsopgave

Transcriptional Regulation of De Novo Lipogenesis in Liver
1
The Molecular Basis of†Hepatic De Novo Lipogenesis in†Insulin Resistance
32
Regulation of†Hepatic Metabolism by†the†Mechanistic Target of†Rapamycin
59
FoxO1 A†Conductor of†Insulin Signaling to†Glucose and†Lipid Metabolism
79
Molecular Mechanisms of†Lipotoxicity in†Nonalcoholic Fatty Liver Disease
101
Role of†the†Endocannabinoid System in†Hepatic Lipogenesis
130
Role of†Lipogenesis and†Lipid Desaturases in†Nonalcoholic Fatty Liver Disease
143
Lipid Droplet Proteins and†Hepatic Lipid Metabolism
165
Influence of†Gut Microbiota on†Hepatic Lipogenesis and†Disease Pathogenesis
189
Hepatic Lipogenesis Nutritional Control and†Pathophysiological Relevance
211
Metabolic Rhythm of†Hepatic Lipogenesis Regulation and†Roles in†Metabolism
235
Monounsaturated Fatty Acid Mediated LiverAdipose Tissue Crosstalk and†Metabolic Regulation
254
Adipose Tissue DNL and†Its Role in†Metabolic Homeostasis
267
The Lipogenic Effect of†Insulin Revisited
284
Index
297
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Over de auteur (2015)

James M. Ntambi, PhD, is the Katherine Berns Von Donk Steenbock Professor in Nutrition, Department of Chemistry, College of Agricultural and Life Sciences, at the University of Wisconsin, Madison.

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